Association of serum bilirubin in newborns affected by jaundice with gut microbiota dysbiosis. Gut metagenome of IC

Breast milk jaundice (BMJ) is common and benign, but neonatal cholestasis (NC) is rare and not benign, so early differentiation between NC and non-NC jaundice is important and may facilitate diagnosis and treatment. Gut microbiota plays an important role in enterohepatic circulation, which in turn plays an important role in the secretion of bilirubin. To determine the composition of gut microbiota in patients with NC and BMJ, and to identify the gut microbiota composition associated with NC and BMJ.Shotgun metagenomic sequencing and metagenome-wide association were performed on Forty NC patients, 16 patients affected by BMJ, and 14 healthy controls (CON) without jaundice.