Supplementary Material: Body composition and inflammation impact in non-small cell lung cancer patients treated by first line immunotherapy

Table 1 Supplementary
Material. Study with mono-immunotherapy in first line in NSCLC: CheckMate 026
and Keynote 024
Table 2 Supplementary
Material. Variation of blood exams and CT scan values from baseline to first
re-staging°
Table 3 Supplementary
Material. Correlation between different characteristics of patients
Table 4 Supplementary
Material. Overall Survival Univariate analysis with baseline WBC, albumin,
CRP and NLR considered as continuous variable and Multivariate analysis with
WBC, albumin, SMI and VSR as continuous variables

Figure 1 Supplementary
Material. Kaplan-Meier Overall Survival curves according to SFI and CRP
variation
Figure 2
Supplementary Material. Selected CT scan parameters (3 for muscle mass and 3
for adipose tissue) in relation with response, comparing values at baseline
and first re-staging
Figure 3
Supplementary Material: ROC curves and Kaplan Meier (KM) Overall Survival
curves according to selected parameters. A: white blood cell (WBC), B:
albumin, C: C-reactive protein (CRP). 1: ROC curves; 2: KM curves divided
with cut-offs derived from ROC curves, 3: KM curves divided with median, 4:
KM curves divided with selected cut-offs (upper normal limit (UNL) or low
normal limit (LNL).
Figure 4
Supplementary Material: ROC curves and Kaplan Meier (KM) Overall Survival
curves according to selected parameters. D: Neutrophil-to-lymphocyte ratio
(NLR), E: Skeletal Muscle Index (SMI), F: Advance lung cancer inflammation
index (ALI score). 1: ROC curves; 2: KM curves divided with cut-offs derived
from ROC curves, 3: KM curves divided with median, 4: KM curves divided with
selected cut-offs derived from literature (c.o.).

Figure 5
Supplementary Material. SMI, VSR, albumin and CRP at baseline in relation
with response in our patients.
Figure 6
Supplementary Material. Relationship between classes of BMI and weight loss
and mOS in our patients