ASSESSMENT OF REGIONAL RISK FACTORS FOR THE DEVELOPMENT OF PRIMARY ARTERIAL HYPERTENSION AND CARDIOMETABOLIC SYNDROME IN YOUNG ADULTS

Abstract. The escalating global incidence of cardiovascular and metabolic disorders among the youth demographic represents a formidable challenge for contemporary preventive medicine. This expanded epidemiological study investigates the specific regional determinants driving the early onset of primary arterial hypertension and cardiometabolic syndrome in young adults (aged 18–35) residing in the Andijan region of the Republic of Uzbekistan. Utilizing a prospective, cross-sectional analytical design, a robust cohort of 850 participants was comprehensively evaluated through detailed anthropometric profiling, continuous blood pressure monitoring, and extensive biochemical assays (lipid spectrum, fasting plasma glucose, and insulin resistance indicators). The empirical results revealed a concerning epidemiological shift: 16.4% of the screened youth exhibited primary arterial hypertension, while 14.1% met the stringent diagnostic criteria for cardiometabolic syndrome. Multivariate logistic regression analysis identified a profound correlation between the manifestation of these pathologies and specific regional behavioral vectors, most notably a sedentary lifestyle, high dietary sodium intake, and the frequent consumption of traditional meals characterized by high glycemic indices and saturated animal fats. Furthermore, central obesity and atherogenic dyslipidemia were established as the most potent independent predictors of metabolic deterioration in this cohort. The discussion contextualizes these findings within the rapid urbanization of the Fergana Valley, emphasizing the urgent need to pivot public health strategies from geriatric management to aggressive, youth-targeted primary prevention. The study concludes that implementing university-based metabolic screening protocols and culturally tailored nutritional education is imperative to mitigate the future cardiovascular burden in the region.