Susceptibility of clade 2.1 HPAI H5N1 isolates from Indonesia to zanamivir and oseltamivir in the enzyme inhibition assay.

aSamples were all assayed with a 30 min preincubation with inhibitor, and then MUNANA was added and reactions were stopped after 60 min and read. Samples were tested in duplicate and means and SDs for reference controls are from all assays in each batch, with six assays in the first batch and five in the second.bMeans for each batch were calculated on log10 transformed data, and then back transformed.cExcluding 2 most extreme outliers with IC50s >260 nM.dIQR Interquartile range representing the range in which 50% of values fall (25th-75th percentile).eMild outliers defined as 1.5xIQR from the 75th percentile.fExtreme outliers defined as 3xIQR from the 75th percentile.gClade 1 strain sensitive to both zanamivir and oseltamivir.hClade 1 Cambodian strain with small reduction in oseltamivir sensitivity.iClade 2 Indonesian strain with higher reduction in oseltamivir sensitivity.