Genetic Heterogeneity and Evolutionary History of High-Grade Ovarian Carcinoma and Matched Distant Metastases

High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian carcinoma, associated with poor clinical outcome and metastatic disease. Although, metastatic processes are becoming more understandable, the genomic landscape and metastatic progression in HGSOC has not been elucidated.Multi-region whole-exome sequencing was performed on HGSOC primary tumour region (n=33) and matched germline (n=6) from 6 patients. The resulting somatic variants were analysed to delineate tumour evolution and metastatic dissemination, and to compare the repertoire of events between primary HGSOC and metastasis. This study provides deeper insights into clonal evolution and mutational processes that can pave the way to new therapeutic targets.