Effects of gut microbiota on gene expression in the choroid plexus

Accumulating evidence indicates that gut microbiota dysbiosis is associated with increased blood-brain barrier (BBB) permeability and contributes to Alzheimer’s disease (AD) pathogenesis. In contrast, the influence of gut microbiota on the blood-cerebrospinal fluid (CSF) barrier has not yet been studied. Here, RNA-seq analysis of choroid plexus tissues of normal colonized specific pathogen-free (SPF) versus decolonized antibiotics-treated mice revealed that the barrier function of choroid plexus is affected by the absence of gut microbiota in the AB mice. Comparative gene expression profiling analysis of RNA-seq data from Choroid Plexus of SPF, SPF Reconstituted, Germ-Free, Germ-Free Reconstituted, AB-treated and AB-treated Reconstituted mice