Transcription profiling by array of cerebella from Sbno2-/- mice

This study sought to investigate the role of Strawberry notch homolog 2 (Sbno2), an interleukin-6 (IL-6)-regulated gene whose function is largely unknown, in the central nervous system through the use of a novel mouse model with germline deletion of Sbno2 (Sbno2-/-). In particular, to understand its role in IL-6-mediated neurological disease, these mice were crossed with the GFAP-IL6 transgenic mice, which chronically produces IL-6 from in astrocytes at pathophysiological levels.本研究旨在通过构建草莓缺口同源蛋白2（Strawberry notch homolog 2, Sbno2）种系敲除（Sbno2-/-）的新型小鼠模型，探究该受白细胞介素-6（interleukin-6, IL-6）调控、功能尚不明确的基因在中枢神经系统中的作用。具体而言，为阐明其在IL-6介导的神经系统疾病中的功能，本研究将上述Sbno2敲除小鼠与GFAP-IL6转基因小鼠进行杂交——该转基因小鼠可在星形胶质细胞中以病理生理水平持续表达IL-6。