Defective OGG1 mutants show decreased binding to 8-oxoguanine

OGG1 missense mutants reported in Alzheimer's disease, OGG1 A53T and OGG1 A288V, show decreased DNA glycosylase activity which is due to decreased binding to 8-oxoguanine substrate (Mao et al. 2007). Binding of OGG1 A53T and OGG1 A288V to 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG), a damaged ring-opened guanine that is also an OGG1 substrate, has not been tested.

阿尔茨海默病中报道的 OGG1 突变体 OGG1 A53T 和 OGG1 A288V 表现出 DNA 糖苷酶活性的降低，这种降低是由于与 8-氧鸟嘌呤底物的结合减弱所致（Mao 等人，2007 年）。对于 OGG1 A53T 和 OGG1 A288V 与 2,6-二氨基-4-羟基-5-甲酰胺基嘧啶（FapyG），一种受损的环开合鸟嘌呤，同时也是 OGG1 的底物，其结合情况尚未进行测试。