From behavior to circuit modeling of light-seeking navigation in zebrafish larvae

Bridging brain-scale circuit dynamics and organism-scale behavior is a central challenge in neuroscience. It requires the concurrent development of minimal behavioral and neural circuit models that can quantitatively capture basic sensorimotor operations. Here we focus on light-seeking navigation in zebrafish larvae. Using a virtual reality assay, we first characterize how motor and visual stimulation sequences govern the selection of discrete swim-bout events that subserve the fish navigation in the presence of a distant light source. These mechanisms are combined into a comprehensive Markov-chain model of navigation that quantitatively predict the stationary distribution of the fish’s body orientation under any given illumination profile. We then map this behavioral description onto a neuronal model of the ARTR, a small neural circuit involved in the orientation-selection of swim bouts. We demonstrate that this visually-biased decision-making circuit can similarly capture the statisti..., Data acquisition and pre-processing are described in the associated manuscript, which can be found at:

https://www.biorxiv.org/content/10.1101/810960v1
, Contains Data and Matlab codes for analysis of orientational light-seeking behavior experiments analysis

Data Pooled

Folder 'Data_pooled' contains matlab datafiles with the sequences of navigation under different modalities (see below). Each line is one trajectory. AngleSource is the fish's body angle to the virtual light source, expressed in radian. AngleLab is the fish's body angle in the frame of reference of the laboratory. xCoord and yCoord are the fish center of mass position expressed in pixel size (11,5 px = 1mm). Time of bout (TimeBout) is measured from the onset of the recording sequence, in seconds. FishN is the number of individual fish.

Different modalities :

- No stimulus (Figure 1) :
    'spontaneous_swim.mat'
- Stereo-visual/Contrast-driven orientational phototaxis (Figure 2) :
    'lateralized_exps.mat'
- Temporal orientational phototaxis (Figure 3) :
    'temporal_exps.mat'
- Temporal orientational phototaxis with enucle...