Supplementary Tables S1-S12 from Comprehensive Genetic Characterization of Human Thyroid Cancer Cell Lines: A Validated Panel for Preclinical Studies

Supplementary Table S1. Cell line authentication by Short Tandem Repeat Profiling (STR) Supplementary Table S2. Full list of genetic variants identified by MSK-IMPACT sequencing Supplementary Table S3. Details for identified high-confidence gene rearrangements resulting in in-frame fusion proteins Supplementary Table S4. Recurrent copy number alterations in thyroid cancer cell lines. Supplementary Table S5. Genes located within the recurrent copy number alteration regions. Supplementary Table S6. Differentially expressed genes, which are located within CNA regions. "Matching_CNA_type" column indicates whether the direction of the expression change corresponds to the CNA type (133 out of 134, overexpression for gene amplification and underexpression for gene deletions). Supplementary Table S7. Thyroid cancer cell lines gene expression data. Normalized gene expression values for all genes in the 44 cell lines assessed by Affymetrix expression microarray in this study ("CU" prefix, University of Colorado). Supplementary Table S8. Genes with differential expression in PTC vs. ATC cell lines. List of differentially expressed genes between PTC-derived vs. ATC-derived cell lines (limma, adjusted p-value

补充表 S1：通过短串联重复序列分析（STR）进行的细胞系鉴定
补充表 S2：MSK-IMPACT 测序识别出的全部遗传变异列表
补充表 S3：由高置信度基因重排导致编码框架融合蛋白的详细情况
补充表 S4：甲状腺癌细胞系中的反复发生的拷贝数改变
补充表 S5：位于反复发生的拷贝数改变区域内的基因
补充表 S6：位于拷贝数改变（CNA）区域内的差异表达基因。"Matching_CNA_type" 列表明表达变化的方向是否与 CNA 类型一致（133/134，基因扩增时为过表达，基因缺失时为低表达）。
补充表 S7：甲状腺癌细胞系基因表达数据。本研究中通过 Affymetrix 表达微阵列对 44 个细胞系的所有基因进行标准化基因表达值评估（带有 "CU" 前缀，科罗拉多大学）。
补充表 S8：PTC 与 ATC 细胞系中的差异表达基因。列出 PTC 衍生与 ATC 衍生细胞系之间的差异表达基因列表（limma 调整后的 p 值）