Figure S1 - Preventing Staphylococcus aureus Sepsis through the Inhibition of Its Agglutination in Blood

Direct thrombin inhibitors and their effect on in vitro and in vivo coagulation. (A) Conversion of fibrinogen to fibrin by human alpha-thrombin was measured in the presence or absence of 200 ng argatroban. Human prothrombin was incubated alone as negative control. One arbitrary unit is defined as A450*100. Error bars represent standard deviation of triplicate experiments. (B) Dilute thrombin time was measured for plasma from mice treated with saline (mock) or Dabigatran-etexilate (Dbg) on the day of infection or on day 10 following infection. Each symbol represents a blood sample from a single mouse. Horizontal lines indicate mean thrombin time for the cohort. Statistical significance was determined by two-tailed Student's t-test: *P (PDF)