Multivariable Regression Analyses of the 72-gene Predictive Index in 101 Separate (Non-rebiopsied) Gastric Cancer Patients.

1Result of the Cox regression analysis performed for 101 patients.
2Result of the ordinal logistic regression analysis performed only in 88 patients with measurable disease, using 3 categories of the dependent variable (PR, SD, and PD).
3Hazard ratio.
4Confidence interval.
5Odds ratio.
6Weighted linear combination of log signal values of 72-gene acquired resistance signature. The univariate t-statistics for comparing the acquired chemoresistant state with the pretreatment state were used as the weights.
7Hazard ratio for each unit increase in 72-gene predictive index, which ranges from 1,783 to 2, 075 (i.e., the highest predictive index (2,075) and median predictive index (1,945) are associated with hazard ratios of 4.3 ( = 1.005292) and 2.2 ( = 1.005162), respectively, compared with a hazard ratio of 1.0 with the lowest predictive index (1,783) of all 101 samples).
8Eastern Cooperative Oncology Group Performance Status.
9as compared with ECOG PS 0 or 1.
10Hazard ratio for each year increase in age.