ADVANCES AND CHALLENGES IN BIOPHARMACEUTICS: BRIDGING DRUG FORMULATION AND THERAPEUTIC EFFICACY

Biopharmaceutics is a critical discipline within pharmaceutical sciences that examines the relationship between the physicochemical properties of drug substances, dosage forms, and their biological performance. This field integrates principles of pharmaceutics, pharmacokinetics, and drug delivery to optimize therapeutic outcomes. The present article explores the fundamental concepts of biopharmaceutics, including drug absorption, bioavailability, and the Biopharmaceutics Classification System (BCS). It also highlights recent advancements, such as nanotechnology-based delivery systems and personalized medicine approaches, while addressing current challenges in drug development and regulatory evaluation.