BIOGRID CURATED DATA FOR ISD11 (Saccharomyces cerevisiae (S288c))

Protein-Protein, Genetic, and Chemical Interactions for ISD11 (Saccharomyces cerevisiae (S288c)) curated by BioGRID (https://thebiogrid.org); DEFINITION: Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis; exclusive to eukaryotes, implicated as eukaryotic supplement to the bacterium-derived Fe-S cluster (ISC) assembly apparatus; involved in regulation of iron metabolism; member of the LYR protein family

蛋白质-蛋白质、遗传以及化学相互作用数据集，针对ISD11（酿酒酵母S288c菌株）由BioGRID（https://thebiogrid.org）整理；定义：半胱氨酸去硫化酶（Nfs1p）激活剂；对于在吡哆醛磷酸依赖的去硫化半胱氨酸过程中，去硫化酶活性位点处形成过硫化物中间体至关重要；对线粒体铁硫簇生物合成必不可少；仅限于真核生物，被指认为真核生物对细菌来源的铁硫簇（Fe-S cluster，简称ISC）组装装置的补充；参与铁代谢的调节；LYR蛋白家族成员。