The Hereditary Ontology for Gut-Brain Axis Data

We introduce GBO (Gut-Brain Ontology), a structured knowledge base designed to capture the interactions along the gut-brain axis. By formalizing both anatomical and microbiota relationships, GBO enables systematic exploration of how gut microbiota, metabolites, and immune signals influence neurological health and disease. Our primary focus surrounds a large spectrum of disorders from Amyotrophic Lateral Sclerosis, Multiple Sclerosis, Parkinson's disease, Alzheimer's disease, Frontotemporal Dementia, to stroke, diabetes, obesity, and neuropsychiatric conditions such as depression and ADHD; each of them has a connection to the gut-brain interaction. By integrating clinical phenotypes, experimental findings, and molecular pathways into a unified and consistent ontology, GBO will help researchers to discover new risk factors, predict treatment responses, and raise public awareness of the critical role the gut-brain axis plays in human health.