Asymmetric Total Synthesis of Caribenol A via an Intramolecular Diels–Alder Reaction
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https://figshare.com/articles/dataset/Asymmetric_Total_Synthesis_of_Caribenol_A_via_an_Intramolecular_Diels_Alder_Reaction/2407825
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资源简介：
A total
synthesis of the caribenol A (1), a novel
natural product with an intriguing tetracyclic framework, has been
achieved. The synthesis features an intramolecular Diels–Alder
(IMDA) reaction for the facile construction of the tricyclic [5–7–6]
skeleton of caribenol A (1) and a biomimetic oxidation
reaction for the formation of the 2-hydroxyfuran-2(5H)-one motif of caribenol A (1) as key steps. This synthetic
approach also reveals that the sp2 carbon at C(2) in substrate 8 is a critical factor for the formation of the tricyclic
[5–7–6] skeleton in 7.
创建时间：
2016-02-19
