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RNA and miRNA profiles in mouse hepatocytes ApcdeltaHep ROSA or DLK1DeltaWRE

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https://www.ncbi.nlm.nih.gov/sra/SRP382170
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We analyzed the expression of RNAs and microRNAs in hepatocytes isolated from ApcDeltaHep livers, either ROSA26 or deleted for the b-catenin binding site upstream of the DLK1/DIO3 locus by Crispr/Cas9 (DLK1DeltaWRE). We thus explored if editing of this regulatory site impaired the expression of the entire locus and which signaling pathways were modulated. Overall design: RNA profiles from hepatocytes isolated from ApcDeltaHep livers either edited for the Rosa26 locus or the beta-catenin binding site identified upstream of the DLK1/DIO3 locus
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2024-04-01
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