Distinct transcriptional outputs associated with mono- and di-methylated histone H3 arginine 2

Alliance of Genome Resources2026-08-01 收录

组蛋白甲基化抑制剂

转录沉默

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https://www.yeastgenome.org/dataset/GSE14453 数据链接链接失效反馈

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Dimethylation of histone H3 arginine 2 (H3R2me2) maintains transcriptional silencing by inhibiting Set-1 mediated trimethylation of H3K4

Demethylation of the protein phosphatase PP2A promotes demethylation of histones to enable their function as a methyl group sink

表观遗传调控

组蛋白甲基化抑制剂

Dysregulation of chromatin methylation is associated with defects in cellular differentiation as well as a variety of cancers. How cells regulate the opposing activities of histone methyltransferase a

NIAID Data Ecosystem40

X-ray structure of the N-terminus RRM domain of Set1

蛋白质结构解析

组蛋白甲基化抑制剂

X-ray structure of the N-terminus RRM domain of Set1 Descriptor: HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-4 SPECIFIC Authors: Tresaugues, L, Dehe, P.M, Guerois, R, Rodriguez-Gil, A, Varlet, I, Sa

Protein Data Bank Japan2024-05-08 更新20

Histone methylation in rat peripheral nerve. Histone methylation in rat peripheral nerve

表观遗传学

组蛋白甲基化抑制剂

The goal of this study was to determine the distribution of H3K27me3 in rat peripheral nerve, which is formed by PRC2, polycomb repressive complex 2. Overall design: H3K27me3 ChIP samples were prepare

NIAID Data Ecosystem20

H3 K27M and EZHIP impede H3K27-methylation spreading by inhibing allosterically stimulated PRC2 [S2_H3K27me3]

表观遗传调控

组蛋白甲基化抑制剂

In this study, we report that EZHIP and H3 K27M preferentially interact with an allosterically activated form of PRC2 in vivo. The formation of H3 K27M- and EZHIP-PRC2 complexes occurs at CpG islands

NIAID Data Ecosystem30

Genome wide analysis of Suv4-20h1/2 depleted animal caps [dataset1]. Genome wide analysis of Suv4-20h1/2 depleted animal caps [dataset1]

组蛋白甲基化抑制剂

表皮分化

Suv4-20h1/2 are histone methyltransferases that write the H4K20me2 and H4K20me3 marks. We knocked down these enzymes using translation blocking morpholinos in X. tropicalis animal caps and performed R

NIAID Data Ecosystem20

Distinct transcriptional outputs associated with mono- and di-methylated histone H3 arginine 2

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