IP-MS and proteomic analysis of GPR75-interacting proteins in the liver of CDAHFD-induced mice
收藏国家人口健康科学数据中心2026-06-06 收录
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To investigate the mechanism by which GPR75 promotes metabolic dysfunction-associated steatohepatitis (MASH), we performed proteomic analysis on liver tissues from CDAHFD-fed control and hepatocyte-specific Gpr75-knockdown mice. To identify GPR75-interacting proteins, immunoprecipitation coupled with mass spectrometry (IP-MS) was conducted.The SCIEX Triple TOF 5600+ mass spectrometer was used in an information-dependent mode (IDA) to automatically switch between MS and MS/MS spectra. Data were analyzed using ProteinPilot™ software (SCIEX, Concord, ON, Canada) and the UniProtKB database.
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北京蛋白质组研究中心创建时间：
2026-02-26
