microRNA expression profiling in human medulloblastoma

A high throughput microRNA expression profiles was performed in human primary medulloblastoma specimens and relative controls to investigate microRNA involvement in medulloblastoma carcinogenesis. Medulloblastoma is an aggressive brain malignancy with high incidence in childhood. MicroRNA expression analysis has emerged as a powerful tool to identify candidate molecules playing an important role in a large number of malignancies. A high throughput microRNA expression profiles was performed in human primary medulloblastoma specimens and relative controls to investigate microRNA involvement in medulloblastoma carcinogenesis. Keywords: RT-PCR In the study presented here we analized expression of a panel of miRNAs in 14 cerebellum controls (9 adult and 5 fetal samples) and in 34 medulloblastoma samples Q-PCR measurement of miRNA expression levels