Farhy2007_hGHregulation

This a model from the article:
Model-projected mechanistic bases for sex differences in growth hormone
regulation in humans.

Farhy LS, Bowers CY, Veldhuis JD. Am J Physiol Regul Integr Comp Physiol
2007 Apr;292(4):R1577-93 17185408
,
Abstract:

Models of physiological systems facilitate rational experimental design,
inference, and prediction. A recent construct of regulated growth hormone (GH)
secretion interlinks the actions of GH-releasing hormone (GHRH), somatostatin
(SRIF), and GH secretagogues (GHS) with GH feedback in the rat (Farhy LS,
Veldhuis JD. Am J Physiol Regul Integr Comp Physiol 288: R1649-R1663, 2005). In
contrast, no comparable formalism exists to explicate GH dynamics in any other
species. The present analyses explore whether a unifying model structure can
represent species- and sex-defined distinctions in the human and rodent. The
consensus principle that GHRH and GHS synergize in vivo but not in vitro was
explicable by assuming that GHS 1) evokes GHRH release from the brain, 2)
opposes inhibition by SRIF both in the hypothalamus and on the pituitary gland,
and 3) stimulates pituitary GH release directly and additively with GHRH. The
gender-selective principle that GH pulses are larger and more irregular in women
than men was conferrable by way of 4) higher GHRH potency and 5) greater GHS
efficacy. The overall construct predicts GHRH/GHS synergy in the human only in
the presence of SRIF when the brain-pituitary nexus is intact, larger and more
irregular GH pulses in women, and observed gender differences in feedback by GH
and the single and paired actions of GHRH, GHS, and SRIF. The proposed model
platform should enhance the framing and interpretation of novel clinical
hypotheses and create a basis for interspecies generalization of GH-axis
regulation.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Farhy LS, Bowers CY, Veldhuis JD. (2007) - version03

The original CellML model was created by:
Lloyd, Catherine, May

[e-mail]
The University of Auckland
The Bioengineering Institute
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