Data of manuscript Blood-perfused Vessels-on-Chips stimulated with patient plasma recapitulate endothelial activation and microthrombosis in COVID-19

This dataset contains the data for the manuscript "Blood-perfused Vessels-on-Chips stimulated with patient plasma recapitulate endothelial activation and microthrombosis in COVID-19", to be published. Within the data are multiple sets:clinical data from included patients and controls; including admission time in hospital, diagnostic measurements when first included, outcome of admission, and VTE status during admissionCytokine ELISAs of IL-6, IL-10, TNF-a, IFN-y, CXCL-10, measured in the derived plasma of hospitalized patientsRaw reads of RNA sequencing of hiPSC derived endothelial cells, after cells were stimulated with diluted patient plasma overnight to induce changes in their phenotypeRaw pathogen counts based on said RNA sequencing data, where non-human RNA reads are quantified per samplePlatelet coverage data after hiPSC-ECs were stimulated with derived plasma on-chip, where the stimulated chips were perfused with human whole blood to recapitulate the thrombotic adverse events that occur in some COVID patients.本数据集对应待发表论文《患者血浆刺激的血流灌注血管芯片可复现新冠肺炎患者内皮激活与微血栓形成》的相关实验数据。数据集包含多组实验数据： 1. 入组患者与健康对照的临床数据，包括住院入院时间、首次入组时的诊断检测指标、住院转归以及住院期间静脉血栓栓塞症（Venous Thromboembolism, VTE）发生情况； 2. 住院患者来源血浆的细胞因子酶联免疫吸附试验（ELISA）检测数据，涵盖IL-6、IL-10、TNF-α、IFN-γ、CXCL-10等指标； 3. 经稀释患者血浆过夜刺激以诱导表型改变的人类诱导多能干细胞（human induced pluripotent stem cells, hiPSC）衍生内皮细胞的RNA测序原始读段（raw reads）数据； 4. 基于上述RNA测序数据的病原体计数数据，即对每个样本中非人类RNA读段进行定量分析的结果； 5. 将患者来源血浆在芯片上刺激人类诱导多能干细胞衍生内皮细胞后，以人全血灌注该刺激芯片以复现部分新冠肺炎患者出现的血栓性不良事件的血小板覆盖度数据。