首页/数据集/Mutant p53R211* specifically suppresses Th17 cell population and ameliorates the arthritic condition in AIA rat via direct binding of TBK1 and inhibition of TBK1-IRF3-STING signaling cascade

Mutant p53R211* specifically suppresses Th17 cell population and ameliorates the arthritic condition in AIA rat via direct binding of TBK1 and inhibition of TBK1-IRF3-STING signaling cascade

Alliance of Genome Resources2026-08-01 收录

关节炎分子机制

p53突变体免疫调控

数据链接：

https://www.ncbi.nlm.nih.gov/gds/?term=GSE221158 数据链接链接失效反馈

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资源简介：

In vivo studies were investigated using rat p53R211* overexpressing adjuvant-induced arthritis (AIA) rat model established by adeno-associated virus (AAV) injection.

应用场景：

关节炎分子机制

转录组差异

Repeated challenge of synovial fibroblasts with MSU crystals in vivo induced inflammatory priming. Overall design: Differential gene expression analysis of cultured synovial fibroblasts derived from n

NIAID Data Ecosystem20

PPARγ controls ESCRT-dependent synoviocyte exosome biogenesis and Alleviates chondrocyte Osteoarthritis by Exosomal ANXA1

关节炎分子机制

外泌体治疗

Osteoarthritis (OA) is characterized by synovitis, cartilage degeneration and exercise therapy has been recognized as first line therapy. The exercise related exosome involved in the interaction betwe

Mendeley Data20

Table_5_Investigating Molecular Signatures Underlying Trapeziometacarpal Osteoarthritis Through the Evaluation of Systemic Cytokine Expression.docx

关节炎分子机制

疾病生物标志物发现

PurposeNon-operative management of trapeziometacarpal osteoarthritis (TMOA) demonstrates only short-term symptomatic alleviation, and no approved disease modifying drugs exist to treat this condition.

NIAID Data Ecosystem10

DataSheet1_Whole-Transcriptome Sequence of Degenerative Meniscus Cells Unveiling Diagnostic Markers and Therapeutic Targets for Osteoarthritis.DOCX

关节炎分子机制

转录组生物标志物

Meniscus plays an important role in joint homeostasis. Tear or degeneration of meniscus might facilitate the process of knee osteoarthritis (OA). Hence, to investigate the transcriptome change during

NIAID Data Ecosystem20

CircPan3 Promotes the Ghrelin System and Chondrocyte Autophagy by Sponging miR-667-5p During Rat Osteoarthritis Pathogenesis [RNA-seq]. CircPan3 Promotes the Ghrelin System and Chondrocyte Autophagy by Sponging miR-667-5p During Rat Osteoarthritis Pathogenesis [RNA-seq]

关节炎分子机制

circRNA分析

This study aimed to investigate the potential roles of circRNAs in regulating osteoarthritis (OA)-related ghrelin synthesis, autophagy induction, and the relevant molecular mechanisms. Overall design:

NIAID Data Ecosystem20

Mutant p53R211* specifically suppresses Th17 cell population and ameliorates the arthritic condition in AIA rat via direct binding of TBK1 and inhibition of TBK1-IRF3-STING signaling cascade

资源简介：

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