Supplementary materials: The societal impact of early intensified treatment in patients with Type 2 diabetes mellitus

These are peer-reviewed supplementary materials for the article 'The societal impact of early intensified treatment in patients with Type 2 diabetes mellitus' published in the Journal of Comparative Effectiveness Research.Figure S1: Fitted parametric distributions for time to treatment failure in the early intensified treatment groupFigure S2: Fitted parametric distributions for time to treatment failure in the stepwise approach groupTable S1: 6-month probabilities of complication events per treatment scenario [1,2]Table S2: Input parameters for the socioeconomic valuationTable S3: Parameter Variation in DSATable S4: Parameter Variation in PSATable S5: Age and gender distributionTable S6: Number of total complication events per treatment strategyTable S7: Avoided productivity losses per avoided event for each complicationTable S8: Societal Impact variation when parameters were varied to their lower and upper bound in the DSAAim: The current study estimates the societal impact of early intensified treatment compared with initial monotherapy with subsequent treatment intensification in newly diagnosed adults with Type 2 diabetes mellitus in Mexico. Methods: An individual patient-level simulation and a static cohort model were employed to simulate the treatment pathway and the probability of experiencing complications of diabetes. The avoided number of events was translated into avoided productivity losses, which were monetized using wages. Results: Patients on early intensified treatment experienced approximately 13,000 fewer complication events over 10 years. This was translated into a societal impact of $54 million (USD). Conclusion: Early treatment intensification is likely to be of particular benefit to health outcomes and productivity losses.