HLA Database
收藏国家生物信息中心2025-10-11 更新2025-08-09 收录
下载链接：
http://bigdata.ibp.ac.cn/HLAtyping
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资源简介：
We genotyped over twenty HLA genes at 3-field resolution in 8278 individuals from diverse ethnic backgrounds, including 4013 unrelated Han Chinese. We focused on the adaptation of HLAs in the Han Chinese by analyzing their binding affinity for various pathogens, and explored the potential correlations between pathogen adaptation and autoimmune diseases. Our findings reveal that specific HLA alleles like HLA-DRB1*07:01 and HLA-DQB1*06:01 confer strong pathogen adaptability at the sequence level, notably for Corynebacterium diphtheriae and Bordetella pertussis.
提供机构：
Institute of Biophysics, Chinese Academy of Sciences
创建时间：
2025-06-27
