A naturally isolated symbiotic bacterium suppresses flavivirus transmission by Aedes mosquitoes
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The commensal microbiota of the mosquito gut plays a complex role in determining the vector competence for arboviruses. Here, we identified a bacterium from the gut of field Aedes albopictus mosquitoes, named Rosenbergiella sp. YN46 (Rosenbergiella_YN46), that rendered mosquitoes refractory to infection with dengue and Zika viruses. Inoculation of 1.6Ã103 colony forming units (CFUs) of Rosenbergiella_YN46 into A. albopictus mosquitoes effectively prevents viral infection. Mechanistically, this bacterium secretes glucose dehydrogenase (RyGDH), which acidifies the gut lumen of fed mosquitoes, causes irreversible conformational changes in the flavivirus envelope protein that prevent viral entry into cells. In semi-field conditions, Rosenbergiella_YN46 exhibits effective transstadial transmission in field mosquitoes, which blocks transmission of dengue virus by newly emerged adult mosquitoes. The prevalence of Rosenbergiella_YN46 is greater in mosquitoes from low-dengue areas (52.9%~91.7%) ..., All methods can be free to access in the published article., , # A naturally isolated symbiotic bacterium suppresses flavivirus transmission by Aedes mosquitoes
This README file was generated on 2024-03-21 by Liming Zhang.
## GENERAL INFORMATION
1. Title of Dataset: A naturally isolated symbiotic bacterium suppresses flavivirus transmission by Aedes mosquitoes
2. Author Information:
A. Principal Investigator Contact Information
Name: Gong Cheng
Institution: Tsinghua University
Address: Beijing, China
Email: [gongcheng@tsinghua.edu.cn](mailto:gongcheng@tsinghua.edu.cn)
B. Co-investigator Contact Information
Name: Yibin Zhu
Institution: Tsinghua University
Address: Beijing, China
Email: [zhuyibin@tsinghua.edu.cn](mailto:zhuyibin@tsinghua.edu.cn)
3. Date of data collection (single date, range, approximate date): 2021-2024
4. Geographic location of data collection: Yunnan, China
5. Information about funding sources that supported the collection of the data: This study was supported by grants fro...
创建时间：
2025-07-29
