Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation
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https://figshare.com/articles/dataset/Identification_of_New_Small-Molecule_Inducers_of_Estrogen-related_Receptor_ERR_Degradation/8006522
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资源简介：
A series of (E)-3-(4-((2,4-bis(trifluoromethyl)benzyl)oxy)-3-methoxyphenyl)-2-cyanoacrylamide
derivatives were designed and synthesized as new estrogen-related
receptor α (ERRα) degraders based on the proteolysis targeting
chimera (PROTAC) concept. One of the representative compounds 6c is capable of specifically degrading ERRα protein
by >80% at a relatively low concentration of 30 nM, becoming one
of
the most potent and selective ERRα degraders to date. Compound 6c could be utilized as a new powerful research tool for further
biological investigation of ERRα.
创建时间：
2019-04-17
