PA is converted to CDP-DAG by CDS2
收藏reactome.org2025-03-23 收录
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At the inner mitochondrial (IM) membrane, phosphatidate cytidylyltransferase 2 (CDS2) converts phosphatidic acid (PA) and cytidine triphosphate (CTP) into cytidine diphosphate-diacylglycerol (CDP-DAG). Both ER and mitochondrial membranes have the capability to synthesise cytidine diphosphate-diacylglycerol (CDP-DAG) with phosphatidate cytidylyltransferase 1 and 2 (CDS1 and CDS2) (Lykidis et al. 1997, Schlame & Haldar 1993). However, transport of CDP-DAG between organelles cannot be ruled out (Stuhne-Sekalec et al. 1986).
在细胞线粒体内膜中,胞苷二磷酸二酰甘油合成酶2(CDS2)将磷脂酸(PA)和胞苷三磷酸(CTP)转化为胞苷二磷酸二酰甘油(CDP-DAG)。内质网(ER)与线粒体膜均具备利用胞苷二磷酸二酰甘油合成酶1和2(CDS1和CDS2)合成胞苷二磷酸二酰甘油(CDP-DAG)的能力(Lykidis等,1997年;Schlame与Haldar,1993年)。然而,CDP-DAG在细胞器之间的运输现象亦不容忽视(Stuhne-Sekalec等,1986年)。
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