Table S1 - Glucose-Raising Genetic Variants in MADD and ADCY5 Impair Conversion of Proinsulin to Insulin

Association of all investigated SNPs (ADCY5 rs11708067, MADD rs7944584, GCK rs4607517, DGKB rs2191349, GCKR rs780094, ADRA2A rs10885122, FADS1 rs174550, CRY2 rs11605924, SLC2A2 rs11920090, GLIS3 rs7034200, PROX1 rs340874, C2CD4B rs11071657) with parameters of glycemia, insulin sensitivity, insulin secretion and proinsulin-to-insulin conversion. Mean values and their standard errors are listed for each genotype. Effect sizes are provided as beta (± standard error). For the linear regression analysis, data were log-transformed. Plasma glucose levels, ISI and HOMA-IR were adjusted for age, sex and BMI. All other parameters were adjusted for age, sex, BMI and ISI. (DOC)