Tissue-specific insulin resistance indices and fasting plasma insulin as predictors of hyperglyceamia at the 5.9-years METSIM follow-up study, Kuopio, Finland.

Abbreviations: B, unstandardized effect size; Beta, standardized regression coefficient; FPG, fasting plasma glucose; Glucose AUC, glucose area under the curve; 2hPG, 2-hour plasma glucose; IR, insulin resistance SE, standard error.Linear regression analysis. Values were calculated using log-transformed variables (except for age). Individuals with type 1 diabetes (N = 25), with known type 2 diabetes (N = 763), newly diagnosed type 2 diabetes at baseline (N = 649) or diagnosed with diabetes between baseline and follow-up (N = 117) were excluded, N = 4,474 for FPG and 2hPG, and 4,450 for glucose AUC. Bold font indicates statistical significance P0.0125.P, adjusted for follow-up time.Pa, adjusted for follow-up time, age, BMI, smoking, physical activity, alcohol consumption and family history of type 2 diabetes.Pb, adjusted for follow-up time, age, BMI, smoking, physical activity, alcohol consumption, family history of type 2 diabetes, and disposition index at baseline.Pc, adjusted for follow-up time age, BMI, smoking, physical activity, alcohol consumption, family history of type 2 diabetes and glucose AUC at baseline.Pd, adjusted for follow-up time, age, BMI, smoking, physical activity, alcohol consumption, family history of type 2 diabetes, disposition index and Glucose AUC at baselin.*Matsuda IR was calculated as: 10/Matsuda ISI.Disposition index was calculated as: Matsuda ISI×InsAUC0–30/GluAUC0–30.Tissue-specific insulin resistance indices and fasting plasma insulin as predictors of hyperglyceamia at the 5.9-years METSIM follow-up study, Kuopio, Finland.