Reporter metabolites for Swedish male dataset.

*Reporter metabolites identified using EHMN metabolic network.
†Reporter metabolites identified in both networks.
§Plant metabolite, likely to be present in the EHMN due to incorrect annotation.
Reporter metabolites with p≤0.05 in at least one of the comparisons showed in bold. Columns with enzyme neighbors show the number of up- and down-regulated enzyme neighbors in the first condition (e.g. T2DM/NGT up- and down-regulated in T2DM comparing with NGT) for each of comparisons. Reporter metabolites without marks were identified using Recon1 metabolic network. Metabolites written in italics are known to be directly/indirectly related to T2DM, see main text and Table S8.