A missense mutation in the coil1A domain of the keratin 25 is associated with the dominant curly hair coat trait (Crd) in horse

Curly horses present a variety of curl phenotypes associated with diverse degrees of curliness of coat, mane, tail and hear hairs. Their origin is still a matter of debate and several genetic hypothesis have been drawn to explain the phenotype diversity, including the combination of autosomal dominant and recessive alleles.This study was set up to map the autosomal dominant “American Bashkir Curly” locus and identify the causative mutation using genome-wide association study (GWAS) and whole genome sequencing approaches