Behavioral, morphological, and multiomics approaches to explore the mechanisms of bisphenol AF exposure-induced neurological disturbances in adult Oryzias melastigma

As a substitute for bisphenol a(BPA), bisphenol AF(BPAF) has been detected in human body fluids and various environmental matrices. Most literatures focus on the endocrine damage of BPAF to freshwater fish. On the contrary, there is not much literature to study how BPAF exposure affects the nervous system homeostasis of Oryzias melastigma. In this study, it was found that the neurometabolic pathways, including tryptophan and tyrosine metabolism, were significantly rich. The molecular mechanism of behavioral inhibition, pathogenic brain changes and abnormal nerve metabolism in adult Oryzias melastigma exposed to BPAF was revealed.