Clinical diagnostic analysis of 504 suspected tuberculosis cases by CRISPR/Cas technology
收藏科学数据银行2023-02-23 更新2026-04-23 收录
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资源简介：
MTB H37Ra could be detected as low as 3.13 CFU/mL by the CRISPR-Cas12a system targeting IS6110. With BACTCE960 culture (120 positives and 384 negatives) as the gold standard, the sensitivity of the TB-CRISPR technique was 0.883 (0.809-0.932) and the specificity was 0.940 (0.910-0.961). According to the receiver operating characteristic (ROC) curve analysis, the area under the curve (AUC) reached 0.944 (0.914-0.975) within 95% CI. The positive likelihood ratio (PLR) was 14.747 (9.870-22.035) and the negative likelihood ratio (NLR) was 0.124 (0.076-0.203). The positive predictive value (PPV) was 0.822 (0.742-0.881) and the negative predictive value (NPV) was 0.963 (0.937-0.979).
提供机构：
Zhaobao Pan; Xiaoyu Zhang; Yubo Zhang; Yueying Huang; Weifang medical university; Department of Laboratory Medicine, the Second People's Hospital of Weifang; XiaoyingHe
创建时间：
2023-02-23
