Gene expression profile of adult ventricular myocytes (AVM) from mouse model B3AR-Tg and WT littermates 9 weeks post TAC surgery

Cardiac ß3-adrenergic receptors (ß3AR) are upregulated in diseased hearts and mediate antithetic effects to those of ß1AR and ß2AR. ß3AR agonists were recently shown to protect from myocardial remodeling in preclinical studies and to improve systolic function in patients with severe heart failure. The mechanisms involved, however, remain elusive. Here we used a transgenic mouse model with moderate, cardiac-specific expression of the human ß3AR (ß3AR-Tg) (with levels similiar to those observed in human cardiac bisopsies) to dissect downstream effects after transaortic constriction (TAC) Overall design: Comparative gene expression profiling between adult ventricular myocytes (AVM) of B3AR-Tg and WT littermates 9 weeks post TAC surgery