ATF2 and ATF7 mediation of intestinal repair in murine colitis model
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE142065
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资源简介：
AP1 transcription factor family members: activating transcription factor 2 (ATF2) and activating transcription factor 7 (ATF7) have highly redundant functions due to homology and hence overlapping DNA-binding sites. The role of these transcription factors in intestinal epithelial homeostasis and repair has not been critically examined. Here, by using an intestine-specific deletion of ATF2 combined with body wide deletion of ATF7 in mice we assess the role of these proteins during intestinal homeostasis and repair after inflammation. 12h treatment of WT and ATF2 KO/ATF7 fl/fl colon organoids with 50ng/ml of recombinant mouse TNF-alpha
创建时间：
2019-12-21
