Pentraxin 3 (PTX-3) and severness of COVID

During the acute phase of COVID-19, elevated levels of several acute phase proteins, such as Creactive protein (CRP), mannose-binding lectin (MBL), pentraxin 3 (PTX-3), serum amyloid A (SAA) and surfactant protein D (SP-D), are associated with severe to fatal clinical outcomes.Typically, these markers return to baseline within days after resolution of the acute infection. In this study, we assessed these proteins in a well-defined cohort of 141 COVID-19 convalescent patients and looked for SNPs in the PTX-3 gene that could serve as biomarkers for the severness of the disease