Ciliberto2003_Swe1Network

This a model from the article:
Mathematical model of the morphogenesis checkpoint in budding yeast.

Ciliberto A, Novak B, Tyson JJ. J Cell Biol
2003 Dec 22;163(6):1243-54 14691135
,
Abstract:

The morphogenesis checkpoint in budding yeast delays progression through the
cell cycle in response to stimuli that prevent bud formation. Central to the
checkpoint mechanism is Swe1 kinase: normally inactive, its activation halts
cell cycle progression in G2. We propose a molecular network for Swe1 control,
based on published observations of budding yeast and analogous control signals
in fission yeast. The proposed Swe1 network is merged with a model of
cyclin-dependent kinase regulation, converted into a set of differential
equations and studied by numerical simulation. The simulations accurately
reproduce the phenotypes of a dozen checkpoint mutants. Among other predictions,
the model attributes a new role to Hsl1, a kinase known to play a role in Swe1
degradation: Hsl1 must also be indirectly responsible for potent inhibition of
Swe1 activity. The model supports the idea that the morphogenesis checkpoint,
like other checkpoints, raises the cell size threshold for progression from one
phase of the cell cycle to the next.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Ciliberto A, Novak B, Tyson JJ. (2003) - version03

The original CellML model was created by:
Lloyd, Catherine, May

[e-mail]
The University of Auckland
The Bioengineering Institute
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