Methylation data from cerebral tumors of WHO grade II and III

Stratification provided six methylation subtypes. We characterized them in terms of genetic alterations, functional context, cellular composition, tumor microenvironment and their possible impact for treatment resistance and prognosis. We here present novel DNA methylation data of an LGG‐cohort collected in the German Glioma Network containing about 85% isocitrate dehydrogenase (IDH) mutated tumors and performed a combined bioinformatics analysis using previously reported genome and transcriptome data. For this study, we screened prospectively recruited patients with a histopathological reference diagnosis of cerebral tumors of WHO grade II and III, known KPS at diagnosis, information on extent of resection by early postoperative neuroimaging, available frozen tissue specimens from the initial operation, and documented clinical outcome. Array‐based DNA methylation data (Illumina 450K arrays) of 122 patient‐matched tumors of the cohort