Participant Characteristics associated with Interest in Using Pre-Exposure Prophylaxis (n = 2 654) One Month after Publication of Efficacy Results (the iPrEx Study).

PrEP = pre-exposure prophylaxis; OR = odds ratio; CI = Confidence Interval; P = level of significance; UAI = unprotected anal intercourse.1Interested in Using PrEP = likely or extremely likely to use PrEP.2Self-perceived risk of HIV acquisition = scale from 1 (no risk) to 10 (extreme risk).Variables that were not statistically significant in bivariate analyses and were not entered into the multivariable model include: monogamous status; race/ethnicity; employment status; annual income; health insurance coverage; transactional sex, UAI after ≥5 drinks and UAI while using recreational drugs - each over the prior 3 months; history of sexually transmitted infection; prior PEP use; contact with any healthcare provider in prior 12 months; identification of a primary care provider (PCP); among participants indicating UAI in prior 3 months, having a PCP who is aware of UAI behaviors; diagnostic history of clinical depression; positive screen for depressive symptoms (Center for Epidemiologic Studies Scale); and prior treatment for drug or alcohol abuse. Variables that were not statistically significant in multivariable analyses include: number of male partners for UAI in the prior 3 months; awareness of PrEP; sexual orientation; gender of sexual partners in prior 3 months; educational attainment; UAI with ≥5 male partners and UAI with ≥1 male partner who is HIV-infected or of unknown serostatus - each over the prior 3 months; comfort discussing same-sex behaviors with PCP; having discussed ways to protect against HIV acquisition with PCP; and positive screen for alcohol abuse (4-item CAGE questionnaire).