Simulation conditions of the responses to an effector as perturbed according to the three modalities that cause response drop, and respective fittings to the model (22).

r2: correlation coefficient between observed and predicted results. See also Table 1 and Figure 4. Number of active receptors (α) and threshold (λ) are defined by means of aleatory Weibull numbers. Doses and perturbator concentrations varie in the natural domain [0-(20)-200] and are coded in the domain [0-(0.1)-1]. pε coefficients –which operate on natural values of D, α and λ– are those defined in (11). Arrows indicate increase (↑) and decrease (↓) of the affected element.