Validation of highly correlated pairs.

The left box under each miRNA column indicates a high positive (+) or negative (−) correlation (|r|>0.916) of that miRNA with the mRNA in each row. The up or down arrow next to the plus or minus sign indicates the expected direction when the miRNA at the top of the column is experimentally changed. miR-182 and 181c were upregulated (⇑) and miR-19a was downregulated (⇓). The observed direction of change is indicated in the right box under each miRNA column. A difference of less than two fold is considered as no change and denoted by a blank.