Methylation Profiling of Blood DNA from Healthy Children (Harvard Age Study)

ChEBI2012-02-24 更新2026-07-21 收录

表观遗传生物标志物

发育表观遗传学

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Methylation Profiling of Blood DNA from Healthy Children (Harvard Age Study)

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2012-02-24

Broad shifts in gene expression during early postnatal life are associated with shifts in histone methylation patterns

组蛋白甲基化分析

发育表观遗传学

During early postnatal life, extensive changes in gene expression occur concomitantly in multiple major organs, indicating the existence of a common core developmental genetic program. This program in

Alliance of Genome Resources70

Competition for H2A.Z underlies the developmental impacts of repetitive element de-repression

发育表观遗传学

染色质调控

The histone variant H2A.Z is central to early embryonic development, determining transcriptional competency through chromatin regulation of gene promoters and enhancers. In addition to genic loci, we

NIAID Data Ecosystem40

Single embryo total RNA sequencing to map the effect of maternal SETDB1 on the 2-celll and 8-cell transcriptome

发育表观遗传学

单细胞转录组学

Embryos with maternal mutation of the H3K9 methyltransferase SETDB1 die before implantation. We tested the role of maternal SETDB1 in the timely processes of the preimplantation stage embryo. Using si

NIAID Data Ecosystem30

Additional file 5: of DNA methylome profiling of all-cause mortality in comparison with age-associated methylation patterns

表观遗传生物标志物

衰老与死亡率分子机制

Table S2 List of pathways enriched by negative mortality association CpGs with FDRâ<â0.05. (XLSX 40 kb)

NIAID Data Ecosystem70

Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate [ISL1_Embryo_Chip_seq]

发育表观遗传学

心肌细胞分化

Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play

NIAID Data Ecosystem40

Methylation Profiling of Blood DNA from Healthy Children (Harvard Age Study)

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