Factors independently associated with interruption in care or death among 405 HIV-infected patients whose initial cART regimen was affected by drug stock-outs, Abidjan, Côte d'Ivoire.

HR: hazard ratio, adjusted for all variables in the table;CNTS: HIV clinic affiliated with the National Center for Blood Transfusion;ZDV: zidovudine; 3TC: lamivudine; d4T: stavudine; EFV: efavirenz; NVP: nevirapine.Other cART regimens: zidovudine-lamivudine-indinavir/ritonavir, lamivudine-stavudine-indinavir/ritonavir, or stavudine-abacavir-efavirenz.Other reasons for modifications are: adverse events, tuberculosis, pregnancy and treatment failure. The reason for modification was unknown for 18 patients (6%).Other reasons for discontinuations are: travel, adverse events, funeral, treatment with traditional remedies, or inability to pay for drugs. The reason for discontinuation was unknown for 657patients (79%).Virologic failure: plasma HIV RNA>300 copies/ml.*Overall p value.**The sensitivity analysis uses an expanded definition of drug stock-out, which includes any treatment discontinuation that lasted more than one month, was not accompanied by an explanation in the medical record, occurred when the pharmacy reported a shortage of at least one of the drugs in the patient's cART regimen.