Modulation of gastro-intestinal permeability induced by 2 weeks consumption with 2 fermented milk products; a randomized, exploratory, cross-over, double blind, controlled study in ileostomy patients

Sugar permeability test in urine samples. 16 volunteers received treatments in different orders (Placebo, L. rhamnosus, Yogurt) and urine was collected after 2 and 5 hours. The samples were collected for the INSIDE explorative dietary study. The study was aimed to characterize the impact of fermented food may have on the small intestinal microbiota and systematically. Sucrose and Lactulose content in the urine was measured. Sucrose is hydrolyzed in the duodenum, and is therefore a good marker for gastroduodenal permeability, measured in 0-5h urine. Lactulose can permeate through the paracellular route and rhamnose through the transcellular route in the small intestine. The ratio in 0-5h urine is mainly used for general assessment of the SI permeability.

尿液样本中的糖渗透性测试。16名志愿者按不同顺序接受了（安慰剂、L. rhamnosus、酸奶）等治疗，并在2小时和5小时后收集尿液。这些样本是为了INSIDE探索性饮食研究而收集的。该研究旨在表征发酵食品可能对小肠微生物群的影响，并系统地评估。尿液中的蔗糖和乳果糖含量被测量。蔗糖在十二指肠中被水解，因此是胃十二指肠渗透性的良好标志物，其在0-5小时尿液中的测量值。乳果糖可以通过小肠的细胞间途径渗透，而山梨糖通过跨细胞途径渗透。0-5小时尿液中的比值主要用于对小肠渗透性的总体评估。