Supplementary Material for: Common Variants in Neuraminidase Genes Contribute to Predisposition to and Progression of Chronic Heart Failure

<b><i>Introduction:</i></b> The role of neuraminidases in cardiovascular disease has recently gained increasing attention. However, the association between neuraminidase gene polymorphisms and heart failure (HF) has not yet been investigated. <b><i>Methods and Results:</i></b> Genotyping of nine single-nucleotide polymorphisms (SNPs) in the NEU2/NEU3/NEU4 genes was performed in 610 HF patients and 600 healthy controls from the Southwest Han Chinese population using TaqMan SNP Genotyping Assay. Individuals carrying the A allele of rs11545301 had decreased risk of HF (additive model: OR = 0.704, 95% CI = 0.511–0.97; <i>p</i> = 0.032). However, the C allele of rs2293763 increased the risk of HF in the recessive model (OR = 1.486, 95% CI = 1.095–2.012; <i>p</i> = 0.011). Rs2233384, rs2233394, and rs2293763 were significantly associated with the mortality risk of HF in the dominant model, both with and without adjustment for conventional risk factors (HR = 0.686, 95% CI = 0.52–0.906, <i>p</i> = 0.008 for rs2233384, HR = 1.357, 95% CI = 1.035–1.78, <i>p</i> = 0.027 for rs2233384, and HR = 0.76, 95% CI = 0.592–0.975, <i>p</i> = 0.031 for rs2293763). <b><i>Conclusion:</i></b> Our findings demonstrated the association between a series of variants in NEU2/NEU4 genes and the risk or prognosis of HF in the Han Chinese population. These data suggested an important role of NEU2 and NEU4 in the pathogenesis of HF.