Telmisartan treated rats still remained lean despite high calorie feeding while gut microbiota was similar to diet induced obese rats. Rat microbiome and its response to diet

We demonstrated in rodents that telmisartan (TEL) has antiobese efficacy when highly dosed. Even though this effect seems to be dependent on a leptin and an Ang(1-7)/Mas dependent pathway the exact mechanism is still a matter of debate. We here firstly investigated whether a gut related mechanism is involved.