RNA-sequencing for dynamic epi-transcriptomic landscape mapping with disease progression in ER-positive breast cancer. RNA-sequencing for dynamic epi-transcriptomic landscape mapping with disease progression in ER-positive breast cancer

Advanced breast cancer is characterised by enhanced tumour adaptability to therapeutic pressure and the metastatic microenvironment. Transcriptome differences in three ER positive (ER+) cell models are uncovered through this RNA-seq analysis of MCF7 (endocrine sensitive), LY2 (endocrine resistant) and T347 (derived from an ER-positive, treatment resistant brain metastatic patient tumour) cells. Overall design: We report the RNA-sequencing of three ER positive (ER+) cell models: MCF7, LY2 and T347 cells, and examine the gene expression differences.