Data for: A numerical study of a left ventricular expander for heart failure with preserved ejection fraction

Increased cardiac stiffness hinders proper left ventricular (LV)
expansion, resulting in decreased volume, delayed filling, and diastolic
dysfunction. LV expanders are spring-like devices that aim to improve
diastolic function by facilitating mechanical outward expansion.
Implantations in animal models and in a few patients have shown promising
results, yet further evaluation is needed to assess range of function and
the risk of use. In this computational study, the effectiveness and
potential use of a generic LV expander were assessed by utilising our
finite element models of HFpEF-induced animal subjects. Following
implantation, the treated models were compared to the corresponding
untreated and healthy preinduction models. Influence of device orientation
and its material properties was also examined. Our results demonstrated a
reduction in LV pressure and a volumetric improvement. Computed LV
stresses have shown no gross irregularities. The device contributed to
stress elevation during diastole while having a minor effect during
systole, supporting a basic safety profile. This is the first study to use
numerical analysis to assess LV expanders’ performance on different HFpEF
phenotypes. Improvement in heart function was demonstrated in both
subjects, suggesting its potential use in various HFpEF manifestations,
yet customisation and optimal deployment are essential to improve heart
performance.