LPAR signaling activated in neural crest stem cells promotes melanoma cell growth, invasion and therapy resistance [HumanWG6_V2]. Homo sapiens

To pinpoint developmental pathways that are up-regulated both in neural crest stem cells (NCSC) and in melanoma cells but not in melanocytes, we carried out computational analyses to compare gene expression profiles of human skin-derived NCSC, epidermal melanocytes and melanoma cells. Our aim was to preselect genes that exhibit high mRNA expression levels both in melanoma cells and in NCSC but low levels in melanocytes. Overall design: The microarray data were generated in our laboratory from six melanoma cell lines, six NCSC samples and four melanocyte samples.